Teriflunomide

Late intrauterine deaths (> 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3148
R4959		 Barataud-Reilhac A (Control exposed to IFN or GLA), 2019 Stillbirth (NOS) during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 14.46 [0.28;737.16] C
excluded (control group) 		0/47   0/673 0 47
ref
S3147
R4952		 Barataud-Reilhac A (Control unexposed, sick), 2019 Stillbirth (NOS) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: No 1.56 [0.09;27.10] C 0/47   10/1,538 10 47
ref
Total 1 studies 1.56 [0.09;27.10] 10 47
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Barataud-Reilhac A (Control unexposed, sick), 2019Barataud-Reilhac A, 2019 1 1.56[0.09; 27.10]10470%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.56[0.09; 27.10]1047 -NABarataud-Reilhac A (Control unexposed, sick), 2019 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.56[0.09; 27.10]1047 -NABarataud-Reilhac A (Control unexposed, sick), 2019 1 Tags Adjustment   - No  - No 1.56[0.09; 27.10]1047 -NABarataud-Reilhac A (Control unexposed, sick), 2019 1 All studiesAll studies 1.56[0.09; 27.10]1047 -NABarataud-Reilhac A (Control unexposed, sick), 2019 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3148

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.56[0.09; 27.10]1047 -NABarataud-Reilhac A (Control unexposed, sick), 2019 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale14.46[0.28; 737.16]-47 -NABarataud-Reilhac A (Control exposed to IFN or GLA), 2019 10.510.01.0