TNF-alpha inhibitors

Macrosomia (> 4000g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4958
R12996		 De Lorenzo (Controls unexposed, disease free), 2020 Large for gestational age at least 1st trimester retrospective cohort unexposed, disease free excluded Adjustment: No 0.24 [0.01;4.72] C
excluded (control group) 		0/12   5/36 5 12
ref
S4959
R13002		 De Lorenzo (Controls unexposed, sick), 2020 Large for gestational age at least 1st trimester retrospective cohort unexposed, sick Adjustment: No 2.74 [0.05;146.26] C 0/12   0/32 0 12
ref
S3069
R4678		 Agosti, 2015 Macrosomia during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No 3.13 [0.12;81.01] C 1/24   0/24 1 24
ref
Total 2 studies 2.97 [0.24;36.82] 1 36
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF De Lorenzo (Controls unexposed, sick), 2020De Lorenzo, 2020 1 2.74[0.05; 146.26]01240%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Agosti, 2015Agosti, 2015 3.13[0.12; 81.01]12460%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 2.97[0.24; 36.82]1360.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.97[0.24; 36.82]1360%NADe Lorenzo (Controls unexposed, sick), 2020 Agosti, 2015 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.97[0.24; 36.82]1360%NADe Lorenzo (Controls unexposed, sick), 2020 Agosti, 2015 2 Tags Adjustment   - No  - No 2.97[0.24; 36.82]1360%NADe Lorenzo (Controls unexposed, sick), 2020 Agosti, 2015 2 All studiesAll studies 2.97[0.24; 36.82]1360%NADe Lorenzo (Controls unexposed, sick), 2020 Agosti, 2015 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 4958

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale0.24[0.01; 4.72]512 -NADe Lorenzo (Controls unexposed, disease free), 2020 1 unexposed, sick controlsunexposed, sick controls 2.97[0.24; 36.82]1360%NADe Lorenzo (Controls unexposed, sick), 2020 Agosti, 2015 20.510.01.0