TNF-alpha inhibitors

Oro-facial clefts

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4098
R8754
Carman - Etanercept (Controls unexposed, disease free), 2017 Oral‐facial malformations during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, disease free excluded Adjustment: No 5.17 [0.72;36.93] C
excluded (control group)
2/210   2/1,078 4 210
ref
S4099
R8769
Carman - Etanercept (Controls unexposed, sick), 2017 Oral‐facial malformations during pregnancy (anytime or not specified) excluded retrospective cohort (claims database) unexposed, sick Adjustment: No 9.28 [1.30;66.22] C
excluded (exposition period)
2/210   2/1,932 4 210
ref
S3194
R5161
Bröms a (Controls unexposed, disease free), 2016 Cleft, lip, palate 3 months or more before pregnancy or1st trimester population based cohort retrospective unexposed, disease free excluded Adjustment: No 0.41 [0.03;6.51] C
excluded (control group)
0/683   2,248/1,250,192 2,248 683
ref
S3193
R5139
Bröms a (Controls unexposed, sick), 2016 Cleft, lip, palate 3 months or more before pregnancy or1st trimester excluded population based cohort retrospective unexposed, sick Adjustment: Yes 0.43 [0.03;7.04] C
excluded (exposition period)
0/683   36/21,549 36 683
ref
Total 0 studies NaN [NaN;NaN] 0 0
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis