TNF-alpha inhibitors

Respiratory system anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4098
R8755
Carman - Etanercept (Controls unexposed, disease free), 2017 Respiratory malformations during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, disease free excluded Adjustment: No 1.03 [0.12;8.83] C
excluded (control group)
1/210   5/1,078 6 210
ref
S4099
R8770
Carman - Etanercept (Controls unexposed, sick), 2017 Respiratory malformations during pregnancy (anytime or not specified) excluded retrospective cohort (claims database) unexposed, sick Adjustment: No 2.31 [0.26;20.73] C
excluded (exposition period)
1/210   4/1,932 5 210
ref
S3194
R5160
Bröms a (Controls unexposed, disease free), 2016 Respiratory system 3 months or more before pregnancy or1st trimester population based cohort retrospective unexposed, disease free excluded Adjustment: No 1.69 [0.42;6.78] C
excluded (control group)
2/683   2,167/1,250,192 2,169 683
ref
S3193
R5138
Bröms a (Controls unexposed, sick), 2016 Respiratory system 3 months or more before pregnancy or1st trimester excluded population based cohort retrospective unexposed, sick Adjustment: Yes 1.78 [0.29;5.89]
excluded (exposition period)
2/683   42/21,549 44 683
ref
Total 0 studies NaN [NaN;NaN] 0 0
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis