TNF-alpha inhibitors

Ectopic pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4995
R13081		 Drechsel, 2020 Ectopic pregnancy 1st trimester prospective cohort unexposed, sick Adjustment: No 13.00 [0.51;331.38] C 1/21   0/85 1 21
ref
S2897
R4079		 Diav-Citrin (Controls exposed to other treatments), 2014 Ectopic pregnancy 1st trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No 3.15 [0.13;78.38] C
excluded (control group) 		1/83   0/86 1 83
ref
S2893
R4064		 Diav-Citrin (Controls unexposed, disease free), 2014 Ectopic pregnancy 1st trimester prospective cohort unexposed, disease free Adjustment: No 12.53 [0.51;310.51] C 1/83   0/341 1 83
ref
Total 2 studies 12.76 [1.31;124.74] 2 104
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Drechsel, 2020Drechsel, 2020 13.00[0.51; 331.38]12150%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Diav-Citrin (Controls unexposed, disease free), 2014Diav-Citrin, 2014 1 12.53[0.51; 310.51]18350%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 12.76[1.31; 124.74]21040.950.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, disease free;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 12.76[1.31; 124.74]21040%NADrechsel, 2020 Diav-Citrin (Controls unexposed, disease free), 2014 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 12.53[0.51; 310.51]183 -NADiav-Citrin (Controls unexposed, disease free), 2014 1 unexposed, sickunexposed, sick 13.00[0.51; 331.38]121 -NADrechsel, 2020 1 Tags Adjustment   - No  - No 12.76[1.31; 124.74]21040%NADrechsel, 2020 Diav-Citrin (Controls unexposed, disease free), 2014 2 All studiesAll studies 12.76[1.31; 124.74]21040%NADrechsel, 2020 Diav-Citrin (Controls unexposed, disease free), 2014 20.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 2897

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale12.53[0.51; 310.51]183 -NADiav-Citrin (Controls unexposed, disease free), 2014 1 unexposed, sick controlsunexposed, sick controls Out of scale13.00[0.51; 331.38]121 -NADrechsel, 2020 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 3.15[0.13; 78.38]183 -NADiav-Citrin (Controls exposed to other treatments), 2014 10.510.01.0