TNF-alpha inhibitors

Cardiac septal defects

id	Study   Auto Bröms a (Controls unexposed, disease free), 2016Bröms a (Controls unexposed, sick), 2016	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimester	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S3194 R8742	Bröms a (Controls unexposed, disease free), 2016	Cardiac septal defects	3 months or more before pregnancy or1st trimester	population based cohort retrospective	unexposed, disease free excluded	Adjustment: No	2.00 [1.20;3.33] C excluded (control group)	15/683   13,901/1,250,192	13,916	683		ref
S3193 R8743	Bröms a (Controls unexposed, sick), 2016	Cardiac septal defects	3 months or more before pregnancy or1st trimester excluded	population based cohort retrospective	unexposed, sick	Adjustment: No	1.75 [1.03;2.96] C excluded (exposition period)	15/683   273/21,549	288	683		ref
					Total	0 studies	NaN [NaN;NaN]		0	0
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis