TNF-alpha inhibitors

Neonatal death (< 28 days of life)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4995
R13094		 Drechsel, 2020 Neonatal death (0-7 days) 1st trimester prospective cohort unexposed, sick Adjustment: No 4.85 [0.09;255.42] C 0/14   0/66 0 14
ref
S3037
R4572		 Seirafi, 2014 Neonatal death (NOS) 3 months (or more) before pregnancy or during pregnancy excluded retrospective cohort unexposed, sick Adjustment: No before conception and/or during pregnancy 0.76 [0.05;12.33] C
excluded (exposition period) 		1/118   1/90 2 118
ref
S2916
R4129		 Verstappen, 2011 Neonatal death (NOS) early pregnancy prospective cohort unexposed, sick Adjustment: No 4.24 [0.17;106.23] C 1/50   0/69 1 50
ref
Total 2 studies 4.47 [0.37;54.48] 1 64
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Drechsel, 2020Drechsel, 2020 4.85[0.09; 255.42]01440%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Verstappen, 2011Verstappen, 2011 4.24[0.17; 106.23]15060%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 4.47[0.37; 54.48]1640.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 4.47[0.37; 54.48]1640%NADrechsel, 2020 Verstappen, 2011 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 4.47[0.37; 54.48]1640%NADrechsel, 2020 Verstappen, 2011 2 Tags Adjustment   - No  - No 4.47[0.37; 54.48]1640%NADrechsel, 2020 Verstappen, 2011 2 All studiesAll studies 4.47[0.37; 54.48]1640%NADrechsel, 2020 Verstappen, 2011 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 4.47[0.37; 54.48]1640%NADrechsel, 2020 Verstappen, 2011 20.510.01.0