TNF-alpha inhibitors

Preeclampsia

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4995
R13083		 Drechsel, 2020 Preeclampsia 1st trimester prospective cohort unexposed, sick Adjustment: No 2.46 [0.21;29.20] C 1/14   2/66 3 14
ref
S4997
R13102		 Fu - Etanercept, 2019 Gestational hypertension 1st trimester randomized controlled trial unexposed, sick Adjustment: Randomisation 0.13 [0.02;1.08] C 1/95   7/93 8 95
ref
S3066
R4660		 Chaparro, 2018 Eclampsia 3 months (or more) before pregnancy or during pregnancy excluded retrospective cohort unexposed, sick Adjustment: No 1.47 [0.39;5.50] C
excluded (exposition period) 		5/388   4/453 9 388
ref
Total 2 studies 0.53 [0.03;9.33] 11 109
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Drechsel, 2020Drechsel, 2020 2.46[0.21; 29.20]31448%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Fu - Etanercept, 2019Fu - Etanercept, 2019 0.13[0.02; 1.08]89552%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 68% 0.53[0.03; 9.33]111090.05.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.46[0.21; 29.20]314 -NADrechsel, 2020 1 case control studiescase control studies 0 RCTRCT 0.13[0.02; 1.08]895 -NAFu - Etanercept, 2019 1 Type of controls unexposed, sickunexposed, sick 0.53[0.03; 9.33]1110968%NADrechsel, 2020 Fu - Etanercept, 2019 2 Tags Adjustment   - No  - No 2.46[0.21; 29.20]314 -NADrechsel, 2020 1   - Randomisation  - Randomisation 0.13[0.02; 1.08]895 -NAFu - Etanercept, 2019 1 All studiesAll studies 0.53[0.03; 9.33]1110968%NADrechsel, 2020 Fu - Etanercept, 2019 20.05.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.53[0.03; 9.33]1110968%NADrechsel, 2020 Fu - Etanercept, 2019 20.510.01.0