TNF-alpha inhibitors

Gestational diabetes

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4995
R13087		 Drechsel, 2020 Gestational diabetes 1st trimester prospective cohort unexposed, sick Adjustment: No 1.67 [0.30;9.27] C 2/14   6/66 8 14
ref
S3076
R4721		 Vinet (Controls unexposed, disease free), 2018 Gestational diabetes mellitus during pregnancy (anytime or not specified) retrospective cohort unexposed, disease free excluded Adjustment: No 1.41 [1.10;1.81] C
excluded (control group) 		82/380   2,384/14,596 2,466 380
ref
S3077
R4724		 Vinet (Controls unexposed, sick), 2018 Gestational diabetes mellitus during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No 1.14 [0.87;1.48] C 82/380   483/2,476 565 380
ref
Total 2 studies 1.15 [0.88;1.49] 573 394
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Drechsel, 2020Drechsel, 2020 1.67[0.30; 9.27]8142%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Vinet (Controls unexposed, sick), 2018Vinet, 2018 1 1.14[0.87; 1.48]56538098%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 1.15[0.88; 1.49]5733940.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.15[0.88; 1.49]5733940%NADrechsel, 2020 Vinet (Controls unexposed, sick), 2018 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.15[0.88; 1.49]5733940%NADrechsel, 2020 Vinet (Controls unexposed, sick), 2018 2 Tags Adjustment   - No  - No 1.15[0.88; 1.49]5733940%NADrechsel, 2020 Vinet (Controls unexposed, sick), 2018 2 All studiesAll studies 1.15[0.88; 1.49]5733940%NADrechsel, 2020 Vinet (Controls unexposed, sick), 2018 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3076

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.41[1.10; 1.81]2,466380 -NAVinet (Controls unexposed, disease free), 2018 1 unexposed, sick controlsunexposed, sick controls 1.15[0.88; 1.49]5733940%NADrechsel, 2020 Vinet (Controls unexposed, sick), 2018 20.510.01.0