TNF-alpha inhibitors

Neuro-developmental disorders (as a whole)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3072
R4713		 Duricova, 2019 Some abnormality in neurologic development during pregnancy (anytime or not specified) retrospective cohort unexposed, disease free Adjustment: No 0.81 [0.26;2.53] C 6/72   7/69 13 72
ref
S3069
R4681		 Agosti, 2015 Neurodevelopmental problems during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No 1.00 [0.06;16.97] C 1/24   1/24 2 24
ref
Total 2 studies 0.83 [0.29;2.40] 15 96
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Duricova, 2019Duricova, 2019 0.81[0.26; 2.53]137286%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Agosti, 2015Agosti, 2015 1.00[0.06; 16.97]22414%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 0.83[0.29; 2.40]15960.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.83[0.29; 2.40]15960%NADuricova, 2019 Agosti, 2015 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.81[0.26; 2.53]1372 -NADuricova, 2019 1 unexposed, sickunexposed, sick 1.00[0.06; 16.97]224 -NAAgosti, 2015 1 Tags Adjustment   - No  - No 0.83[0.29; 2.40]15960%NADuricova, 2019 Agosti, 2015 2 All studiesAll studies 0.83[0.29; 2.40]15960%NADuricova, 2019 Agosti, 2015 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.81[0.26; 2.53]1372 -NADuricova, 2019 1 unexposed, sick controlsunexposed, sick controls 1.00[0.06; 16.97]224 -NAAgosti, 2015 10.510.01.0