Adalimumab

Macrosomia (> 4000g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5066
R13188		 De Lorenzo (Controls unexposed, disease free), 2020 Large for gestational age at least 1st trimester retrospective cohort unexposed, disease free excluded Adjustment: No 1.85 [0.07;51.49] C
excluded (control group) 		0/2   5/36 5 2
ref
S5067
R13194		 De Lorenzo (Controls unexposed, sick), 2020 Large for gestational age at least 1st trimester retrospective cohort unexposed, sick Adjustment: No 21.00 [0.30;1469.95] C 0/2   0/32 0 2
ref
Total 1 studies 21.00 [0.30;1469.95] 0 2
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF De Lorenzo (Controls unexposed, sick), 2020De Lorenzo, 2020 1 21.00[0.30; 1469.95]020%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.950.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 21.00[0.30; 1469.95]-2 -NADe Lorenzo (Controls unexposed, sick), 2020 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 21.00[0.30; 1469.95]-2 -NADe Lorenzo (Controls unexposed, sick), 2020 1 Tags Adjustment   - No  - No 21.00[0.30; 1469.95]-2 -NADe Lorenzo (Controls unexposed, sick), 2020 1 All studiesAll studies 21.00[0.30; 1469.95]-2 -NADe Lorenzo (Controls unexposed, sick), 2020 10.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 5066

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.85[0.07; 51.49]52 -NADe Lorenzo (Controls unexposed, disease free), 2020 1 unexposed, sick controlsunexposed, sick controls Out of scale21.00[0.30; 1469.95]-2 -NADe Lorenzo (Controls unexposed, sick), 2020 10.510.01.0