Adalimumab

Elective/induced termination of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5069
R13214		 Chambers (Controls unexposed, disease free), 2019 Elective termination of pregnancy at least 1st trimester prospective cohort unexposed, disease free excluded Adjustment: No 2.64 [0.11;65.04] C
excluded (control group) 		1/257   0/225 1 257
ref
S5068
R13199		 Chambers (Controls, sick), 2019 Elective termination of pregnancy at least 1st trimester prospective cohort unexposed, sick Adjustment: No 1.40 [0.06;34.70] C 1/257   0/120 1 257
ref
S5001
R13116		 Hyrich, 2006 Elective first- trimester terminations 1st trimester retrospective cohort unexposed, sick Adjustment: No 3.40 [0.05;219.14] C 0/3   0/9 0 3
ref
Total 2 studies 1.95 [0.15;24.78] 1 260
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Chambers (Controls, sick), 2019Chambers, 2019 1 1.40[0.06; 34.70]125763%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Hyrich, 2006Hyrich, 2006 3.40[0.05; 219.14]0337%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 1.95[0.15; 24.78]12600.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.95[0.15; 24.78]12600%NAChambers (Controls, sick), 2019 Hyrich, 2006 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.95[0.15; 24.78]12600%NAChambers (Controls, sick), 2019 Hyrich, 2006 2 Tags Adjustment   - No  - No 1.95[0.15; 24.78]12600%NAChambers (Controls, sick), 2019 Hyrich, 2006 2 All studiesAll studies 1.95[0.15; 24.78]12600%NAChambers (Controls, sick), 2019 Hyrich, 2006 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 5069

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.64[0.11; 65.04]1257 -NAChambers (Controls unexposed, disease free), 2019 1 unexposed, sick controlsunexposed, sick controls 1.95[0.15; 24.78]12600%NAChambers (Controls, sick), 2019 Hyrich, 2006 20.510.01.0