Infliximab

Neonatal infections

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3087
R4739		 Vinet (Unexposed controls, disease free), 2018 Serious infections in the offspring (≥1 hospitalization with infection within the first 12 months of life) during pregnancy (anytime or not specified) retrospective cohort unexposed, disease free excluded Adjustment: No 4.53 [1.38;14.83] C
excluded (control group) 		3/37   279/14,596 282 37
ref
S3088
R4740		 Vinet (Unexposed controls, sick), 2018 Serious infections in the offspring (≥1 hospitalization with infection within the first 12 months of life) during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No 4.37 [1.30;14.71] C 3/37   49/2,476 52 37
ref
Total 1 studies 4.37 [1.30;14.71] 52 37
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Vinet (Unexposed controls, sick), 2018Vinet, 2018 1 4.37[1.30; 14.71]52370%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Unexposed controls, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 4.37[1.30; 14.71]5237 -NAVinet (Unexposed controls, sick), 2018 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 4.37[1.30; 14.71]5237 -NAVinet (Unexposed controls, sick), 2018 1 Tags Adjustment   - No  - No 4.37[1.30; 14.71]5237 -NAVinet (Unexposed controls, sick), 2018 1 All studiesAll studies 4.37[1.30; 14.71]5237 -NAVinet (Unexposed controls, sick), 2018 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3087

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 4.53[1.38; 14.83]28237 -NAVinet (Unexposed controls, disease free), 2018 1 unexposed, sick controlsunexposed, sick controls 4.37[1.30; 14.71]5237 -NAVinet (Unexposed controls, sick), 2018 10.510.01.0