Etanercept

Low birth weight (< 2500g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3011
R8688		 Carman (Control unexposed, disease free), 2017 Birth weight <2500 g during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, disease free excluded Adjustment: No 2.20 [1.41;3.44] C
excluded (control group) 		31/217   76/1,081 107 217
ref
S3010
R8689		 Carman (Control unexposed, sick), 2017 Birth weight <2500 g during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: No 1.71 [1.14;2.58] C 31/217   172/1,940 203 217
ref
Total 1 studies 1.71 [1.14;2.58] 203 217
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Carman (Control unexposed, sick), 2017Carman, 2017 1 1.71[1.14; 2.58]2032170%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.71[1.14; 2.58]203217 -NACarman (Control unexposed, sick), 2017 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.71[1.14; 2.58]203217 -NACarman (Control unexposed, sick), 2017 1 Tags Adjustment   - No  - No 1.71[1.14; 2.58]203217 -NACarman (Control unexposed, sick), 2017 1 All studiesAll studies 1.71[1.14; 2.58]203217 -NACarman (Control unexposed, sick), 2017 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3011

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.20[1.41; 3.44]107217 -NACarman (Control unexposed, disease free), 2017 1 unexposed, sick controlsunexposed, sick controls 1.71[1.14; 2.58]203217 -NACarman (Control unexposed, sick), 2017 10.510.01.0