Etanercept

Late intrauterine deaths (> 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4994
R13065		 Drechsel, 2020 Stillbirth 1st trimester prospective cohort unexposed, sick Adjustment: No 2.23 [0.09;57.74] C 0/13   1/85 1 13
ref
S3011
R8686		 Carman (Control unexposed, disease free), 2017 Stillbirth during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, disease free excluded Adjustment: No 0.55 [0.13;2.39] C
excluded (control group) 		2/337   18/1,685 20 337
ref
S3010
R8685		 Carman (Control unexposed, sick), 2017 Stillbirth during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: No 0.68 [0.16;2.87] C 2/337   25/2,861 27 337
ref
Total 2 studies 0.82 [0.22;3.09] 28 350
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Drechsel, 2020Drechsel, 2020 2.23[0.09; 57.74]11316%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Carman (Control unexposed, sick), 2017Carman, 2017 1 0.68[0.16; 2.87]2733784%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 0.82[0.22; 3.09]283500.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.82[0.22; 3.09]283500%NADrechsel, 2020 Carman (Control unexposed, sick), 2017 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.82[0.22; 3.09]283500%NADrechsel, 2020 Carman (Control unexposed, sick), 2017 2 Tags Adjustment   - No  - No 0.82[0.22; 3.09]283500%NADrechsel, 2020 Carman (Control unexposed, sick), 2017 2 All studiesAll studies 0.82[0.22; 3.09]283500%NADrechsel, 2020 Carman (Control unexposed, sick), 2017 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3011

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.55[0.13; 2.39]20337 -NACarman (Control unexposed, disease free), 2017 1 unexposed, sick controlsunexposed, sick controls 0.82[0.22; 3.09]283500%NADrechsel, 2020 Carman (Control unexposed, sick), 2017 20.510.01.0