Etanercept

Neonatal infections

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4994
R13076		 Drechsel, 2020 Neonatal infection (follow up 6 months of age) 1st trimester prospective cohort unexposed, sick Adjustment: No 1.49 [0.07;33.82] C 0/9   2/66 2 9
ref
S3083
R4735		 Vinet (Unexposed controls, disease free), 2018 Serious infections in the offspring (≥1 hospitalization with infection within the first 12 months of life) during pregnancy (anytime or not specified) retrospective cohort unexposed, disease free excluded Adjustment: No 1.91 [0.89;4.10] C
excluded (control group) 		7/195   279/14,596 286 195
ref
S3084
R4736		 Vinet (Unexposed controls, sick), 2018 Serious infections in the offspring (≥1 hospitalization with infection within the first 12 months of life) during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No 1.84 [0.82;4.13] C 7/195   49/2,476 56 195
ref
Total 2 studies 1.82 [0.83;3.97] 58 204
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Drechsel, 2020Drechsel, 2020 1.49[0.07; 33.82]296%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Vinet (Unexposed controls, sick), 2018Vinet, 2018 1 1.84[0.82; 4.13]5619594%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 1.82[0.83; 3.97]582040.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Unexposed controls, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.82[0.83; 3.97]582040%NADrechsel, 2020 Vinet (Unexposed controls, sick), 2018 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.82[0.83; 3.97]582040%NADrechsel, 2020 Vinet (Unexposed controls, sick), 2018 2 Tags Adjustment   - No  - No 1.82[0.83; 3.97]582040%NADrechsel, 2020 Vinet (Unexposed controls, sick), 2018 2 All studiesAll studies 1.82[0.83; 3.97]582040%NADrechsel, 2020 Vinet (Unexposed controls, sick), 2018 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3083

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.91[0.89; 4.10]286195 -NAVinet (Unexposed controls, disease free), 2018 1 unexposed, sick controlsunexposed, sick controls 1.82[0.83; 3.97]582040%NADrechsel, 2020 Vinet (Unexposed controls, sick), 2018 20.510.01.0