Renin-angiotensin system (ACEIs and/or ARBs) (versus unexposed) updated on 03-11-2025

Very preterm (28 to 32 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17123
R71699
Van der Zande - ACE-Is and/or ARBs, 2024 Very preterm (≥28 weeks up to 32 weeks of gestation) during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No Indications Antihypertensive: Only cardiac indications other than hypertension (long QT syndrome, structural heart disease, ...) Renin angiotensin: ARBs and/or ACEIs (Angiotensin II receptor blockers and/or Angiotensin-converting enzyme inhibitors) 3.40 [1.04;11.15] C 3/42   126/5,697 129 42
ref
Total 1 studies 3.40 [1.04;11.15] 129 42
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Van der Zande - ACE-Is and/or ARBs, 2024Van der Zande - ACE-Is and/or ARBs, 2024 3.40[1.04; 11.15]129420%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 3.40[1.04; 11.15]12942 -NAVan der Zande - ACE-Is and/or ARBs, 2024 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 3.40[1.04; 11.15]12942 -NAVan der Zande - ACE-Is and/or ARBs, 2024 1 Tags Adjustment   - No  - No 3.40[1.04; 11.15]12942 -NAVan der Zande - ACE-Is and/or ARBs, 2024 1 Indications Antihypertensive   - Only cardiac indications other than ...  - Only cardiac indications other than hypertension (long QT syndrome, structural heart disease, ...) 3.40[1.04; 11.15]12942 -NAVan der Zande - ACE-Is and/or ARBs, 2024 1 Renin angiotensin   - ARBs and/or ACEIs (Angiotensin II r ...  - ARBs and/or ACEIs (Angiotensin II receptor blockers and/or Angiotensin-converting enzyme inhibitors) 3.40[1.04; 11.15]12942 -NAVan der Zande - ACE-Is and/or ARBs, 2024 1 All studiesAll studies 3.40[1.04; 11.15]12942 -NAVan der Zande - ACE-Is and/or ARBs, 2024 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 3.40[1.04; 11.15]12942 -NAVan der Zande - ACE-Is and/or ARBs, 2024 10.510.01.0