Renin-angiotensin system (ACEIs and/or ARBs) (versus unexposed) updated on 03-11-2025

Ebstein's anomaly

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13437
R51731		 Caton - Renin inhibitors (ACE/ARBs), 2009 Ebstein malformation 1st trimester case control unexposed, disease free Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified Renin angiotensin: ARBs and/or ACEIs (Angiotensin II receptor blockers and/or Angiotensin-converting enzyme inhibitors) 26.40 [2.30;306.00] 1/4   64/4,857 65 4
ref
Total 1 studies 26.40 [2.29;304.51] 65 4
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Caton - Renin inhibitors (ACE/ARBs), 2009Caton - Renin inhibitors, 2009 1 26.40[2.30; 306.00]6540%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.9100.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: ACE/ARBs;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 26.40[2.29; 304.51]654 -NACaton - Renin inhibitors (ACE/ARBs), 2009 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 26.40[2.29; 304.51]654 -NACaton - Renin inhibitors (ACE/ARBs), 2009 1 Tags Adjustment   - No  - No 26.40[2.29; 304.51]654 -NACaton - Renin inhibitors (ACE/ARBs), 2009 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 26.40[2.29; 304.51]654 -NACaton - Renin inhibitors (ACE/ARBs), 2009 1 Renin angiotensin   - ARBs and/or ACEIs (Angiotensin II r ...  - ARBs and/or ACEIs (Angiotensin II receptor blockers and/or Angiotensin-converting enzyme inhibitors) 26.40[2.29; 304.51]654 -NACaton - Renin inhibitors (ACE/ARBs), 2009 1 All studiesAll studies 26.40[2.29; 304.51]654 -NACaton - Renin inhibitors (ACE/ARBs), 2009 10.5100.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale26.40[2.29; 304.51]654 -NACaton - Renin inhibitors (ACE/ARBs), 2009 10.510.01.0