Renin-angiotensin system (ACEIs and/or ARBs) (versus unexposed) updated on 03-11-2025

Coarctation of aorta

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14251
R56024		 Fisher - Renin inhibitors (ACE/ARBs) (Controls unexposed, disease free), 2017 Coarctation of the aorta early pregnancy case control unexposed, disease free excluded Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified Renin angiotensin: ARBs and/or ACEIs (Angiotensin II receptor blockers and/or Angiotensin-converting enzyme inhibitors) 3.10 [0.55;11.75]
excluded (control group) 		3/14   -/- - 14
ref
S14246
R55980		 Fisher - Renin inhibitors (ACE/ARBs) (Controls unexposed, sick), 2017 Coarctation of the aorta early pregnancy case control unexposed, sick Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified Renin angiotensin: ARBs and/or ACEIs (Angiotensin II receptor blockers and/or Angiotensin-converting enzyme inhibitors) 2.19 [0.39;8.47] 3/14   -/- - 14
ref
S14211
R55722		 Colvin - ACEi, 2014 Coarctation of aorta (ICD-9: 7471) 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified Renin angiotensin: ACEIs (Angiotensin-converting enzyme inhibitors) 10.89 [1.02;116.00] -/84   58/97,533 - 84
ref
Total 2 studies 3.76 [0.85;16.59] 0 98
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Fisher - Renin inhibitors (ACE/ARBs) (Controls unexposed, sick), 2017Fisher - Renin inhibitors, 2017 1 2.19[0.39; 8.47]-1466%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Colvin - ACEi, 2014Colvin - ACEi, 2014 10.89[1.02; 116.00]-8434%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: critical Total (2 studies) I2 = 19% 3.76[0.85; 16.59]-980.950.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: ACE/ARBs) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 10.89[1.02; 116.13]-84 -NAColvin - ACEi, 2014 1 case control studiescase control studies 2.19[0.47; 10.21]-14 -NAFisher - Renin inhibitors (ACE/ARBs) (Controls unexposed, sick), 2017 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 10.89[1.02; 116.13]-84 -NAColvin - ACEi, 2014 1 unexposed, sickunexposed, sick 2.19[0.47; 10.21]-14 -NAFisher - Renin inhibitors (ACE/ARBs) (Controls unexposed, sick), 2017 1 Tags Adjustment   - No  - No 2.19[0.47; 10.21]-14 -NAFisher - Renin inhibitors (ACE/ARBs) (Controls unexposed, sick), 2017 1   - Yes  - Yes 10.89[1.02; 116.13]-84 -NAColvin - ACEi, 2014 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 3.76[0.85; 16.59]-9819%NAFisher - Renin inhibitors (ACE/ARBs) (Controls unexposed, sick), 2017 Colvin - ACEi, 2014 2 Renin angiotensin   - ACEIs (Angiotensin-converting enzym ...  - ACEIs (Angiotensin-converting enzyme inhibitors) 10.89[1.02; 116.13]-84 -NAColvin - ACEi, 2014 1   - ARBs and/or ACEIs (Angiotensin II r ...  - ARBs and/or ACEIs (Angiotensin II receptor blockers and/or Angiotensin-converting enzyme inhibitors) 2.19[0.47; 10.21]-14 -NAFisher - Renin inhibitors (ACE/ARBs) (Controls unexposed, sick), 2017 1 All studiesAll studies 3.76[0.85; 16.59]-9819%NAFisher - Renin inhibitors (ACE/ARBs) (Controls unexposed, sick), 2017 Colvin - ACEi, 2014 20.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 14251

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 4.49[1.24; 16.24]49980%NAFisher - Renin inhibitors (ACE/ARBs) (Controls unexposed, disease free), 2017 Colvin - ACEi, 2014 2 unexposed, sick controlsunexposed, sick controls 2.19[0.47; 10.21]-14 -NAFisher - Renin inhibitors (ACE/ARBs) (Controls unexposed, sick), 2017 10.510.01.0