Renin-angiotensin system (ACEIs and/or ARBs) (versus unexposed) updated on 03-11-2025

Jaundice / Icterus

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14211
R55734
Colvin - ACEi, 2014 Neonatal jaundice from other and unspecified causes 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified Renin angiotensin: ACEIs (Angiotensin-converting enzyme inhibitors) 2.66 [1.51;4.67] 27/84   7,578/97,533 7,605 84
ref
Total 1 studies 2.66 [1.51;4.68] 7,605 84
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Colvin - ACEi, 2014Colvin - ACEi, 2014 2.66[1.51; 4.67]7,605840%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: critical0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.66[1.51; 4.68]7,60584 -NAColvin - ACEi, 2014 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.66[1.51; 4.68]7,60584 -NAColvin - ACEi, 2014 1 Tags Adjustment   - Yes  - Yes 2.66[1.51; 4.68]7,60584 -NAColvin - ACEi, 2014 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 2.66[1.51; 4.68]7,60584 -NAColvin - ACEi, 2014 1 Renin angiotensin   - ACEIs (Angiotensin-converting enzym ...  - ACEIs (Angiotensin-converting enzyme inhibitors) 2.66[1.51; 4.68]7,60584 -NAColvin - ACEi, 2014 1 All studiesAll studies 2.66[1.51; 4.68]7,60584 -NAColvin - ACEi, 2014 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.66[1.51; 4.68]7,60584 -NAColvin - ACEi, 2014 10.510.01.0