Renin-angiotensin system (ACEIs and/or ARBs) (versus unexposed) updated on 03-11-2025

Ventricular septal defect

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14251
R56027		 Fisher - Renin inhibitors (ACE/ARBs) (Controls unexposed, disease free), 2017 Perimembranous Ventricular septal defect (VSD) early pregnancy case control unexposed, disease free excluded Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified Renin angiotensin: ARBs and/or ACEIs (Angiotensin II receptor blockers and/or Angiotensin-converting enzyme inhibitors) 6.58 [1.55;27.97]
excluded (control group) 		5/-   -/- - -
ref
S14246
R55983		 Fisher - Renin inhibitors (ACE/ARBs) (Controls unexposed, sick), 2017 Perimembranous Ventricular septal defect (VSD) early pregnancy case control unexposed, sick Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified Renin angiotensin: ARBs and/or ACEIs (Angiotensin II receptor blockers and/or Angiotensin-converting enzyme inhibitors) 6.91 [1.43;33.31] 5/-   -/- - -
ref
Total 1 studies 6.91 [1.43;33.35] 0 0
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Fisher - Renin inhibitors (ACE/ARBs) (Controls unexposed, sick), 2017Fisher - Renin inhibitors, 2017 1 6.91[1.43; 33.31]--0%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: ACE/ARBs) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 6.91[1.43; 33.35]-- -NAFisher - Renin inhibitors (ACE/ARBs) (Controls unexposed, sick), 2017 1 Type of controls unexposed, sickunexposed, sick 6.91[1.43; 33.35]-- -NAFisher - Renin inhibitors (ACE/ARBs) (Controls unexposed, sick), 2017 1 Tags Adjustment   - Yes  - Yes 6.91[1.43; 33.35]-- -NAFisher - Renin inhibitors (ACE/ARBs) (Controls unexposed, sick), 2017 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 6.91[1.43; 33.35]-- -NAFisher - Renin inhibitors (ACE/ARBs) (Controls unexposed, sick), 2017 1 Renin angiotensin   - ARBs and/or ACEIs (Angiotensin II r ...  - ARBs and/or ACEIs (Angiotensin II receptor blockers and/or Angiotensin-converting enzyme inhibitors) 6.91[1.43; 33.35]-- -NAFisher - Renin inhibitors (ACE/ARBs) (Controls unexposed, sick), 2017 1 All studiesAll studies 6.91[1.43; 33.35]-- -NAFisher - Renin inhibitors (ACE/ARBs) (Controls unexposed, sick), 2017 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 14251

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 6.58[1.55; 27.95]-- -NAFisher - Renin inhibitors (ACE/ARBs) (Controls unexposed, disease free), 2017 1 unexposed, sick controlsunexposed, sick controls 6.91[1.43; 33.35]-- -NAFisher - Renin inhibitors (ACE/ARBs) (Controls unexposed, sick), 2017 10.510.01.0