Renin-angiotensin system (ACEIs and/or ARBs) (versus unexposed) - Medication and Pregnancy KB

Renin-angiotensin system (ACEIs and/or ARBs) (versus unexposed) updated on 03-11-2025

Maternal consequences (as a whole)

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S17143 R71880	Bane - ACEs/ARB (Controls unexposed sick), 2024	Severe maternal morbidity (acute renal failure, sepsis, eclampsia, cardiac arrest/ventricular fibrillation, ventilation, ...)	during pregnancy (anytime or not specified)	retrospective cohort (claims database)	unexposed, sick	Adjustment: No Indications Antihypertensive: Only chronic hypertension indication	1.22 [0.88;1.68] ^C	191/2,520 50/791	241	2,520		ref
					Total	1 studies	1.22 [0.88;1.68]		241	2,520
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed sick;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded