Centrally acting antiadrenergic (versus unexposed) updated on 03-11-2025

Intrauterine deaths (as a whole or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13538
R52306		 Weitz - Methyldopa, 1987 Fetal morbidity (NOS) during pregnancy (anytime or not specified) randomized controlled trial unexposed, sick Adjustment: Randomisation Indications Antihypertensive: Only chronic hypertension indication 0.10 [0.00;2.13] C 0/13   3/12 3 13
ref
Total 1 studies 0.10 [0.00;2.13] 3 13
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Weitz - Methyldopa, 1987Weitz - Methyldopa, 1987 0.10[0.00; 2.13]3130%ROB confusion: lowROB selection: unclearROB classification: lowROB missing: lowROB mesure: lowROB reporting: moderate0.02.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0 RCTRCT 0.10[0.00; 2.13]313 -NAWeitz - Methyldopa, 1987 1 Type of controls unexposed, sickunexposed, sick 0.10[0.00; 2.13]313 -NAWeitz - Methyldopa, 1987 1 Tags Adjustment   - Randomisation  - Randomisation 0.10[0.00; 2.13]313 -NAWeitz - Methyldopa, 1987 1 Indications Antihypertensive   - Only chronic hypertension indication  - Only chronic hypertension indication 0.10[0.00; 2.13]313 -NAWeitz - Methyldopa, 1987 1 All studiesAll studies 0.10[0.00; 2.13]313 -NAWeitz - Methyldopa, 1987 10.010.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale0.10[0.00; 2.13]313 -NAWeitz - Methyldopa, 1987 10.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Abalos (Total reported fetal or neonatal deat ...Abalos (Total reported fetal or neonatal death (including miscarriage) (RCT versus no antihypertensive drugs/placebo)) Out of scale0.35[0.06; 2.10]59%-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT3 metaPregmetaPreg Out of scale0.10[0.00; 2.13]NaN%13----Weitz - Methyldopa, 1987 10.510.01.0