Centrally acting antiadrenergic (versus unexposed) updated on 03-11-2025

Chromosomal abnormalities

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13390
R51885		 Hoeltzenbein - Methyldopa (Controls unexposed, disease free), 2017 Genetic anomalies at least 1st trimester prospective cohort unexposed, disease free Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified 1.96 [0.12;31.52] C 1/246   1/482 2 246
ref
Total 1 studies 1.96 [0.12;31.52] 2 246
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Hoeltzenbein - Methyldopa (Controls unexposed, disease free), 2017Hoeltzenbein - Methyldopa, 2017 1 1.96[0.12; 31.52]22460%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: low0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, disease free;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.96[0.12; 31.52]2246 -NAHoeltzenbein - Methyldopa (Controls unexposed, disease free), 2017 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.96[0.12; 31.52]2246 -NAHoeltzenbein - Methyldopa (Controls unexposed, disease free), 2017 1 Tags Adjustment   - No  - No 1.96[0.12; 31.52]2246 -NAHoeltzenbein - Methyldopa (Controls unexposed, disease free), 2017 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 1.96[0.12; 31.52]2246 -NAHoeltzenbein - Methyldopa (Controls unexposed, disease free), 2017 1 All studiesAll studies 1.96[0.12; 31.52]2246 -NAHoeltzenbein - Methyldopa (Controls unexposed, disease free), 2017 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.96[0.12; 31.52]2246 -NAHoeltzenbein - Methyldopa (Controls unexposed, disease free), 2017 10.510.01.0