Centrally acting antiadrenergic (versus unexposed) updated on 03-11-2025

Cognitive developmental disorders/delay (> 6 years old)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17124
R71716		 Huisjes - Clonidine, 1986 Minor neurological dysfunction (overtly handicapping condition, such as mild diffuse hypotonia, mild problems in coordination or fine manipulative ability) - Touwen test - At ages varying from 3 to 9.5 years (mean 6-7 years) during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified Matched 0.80 [0.22;2.94] C 6/22   7/22 13 22
ref
Total 1 studies 0.80 [0.22;2.94] 13 22
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Huisjes - Clonidine, 1986Huisjes - Clonidine, 1986 0.80[0.22; 2.94]13220%ROB confusion: seriousROB selection: unclearROB classification: unclearROB missing: unclearROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.80[0.22; 2.94]1322 -NAHuisjes - Clonidine, 1986 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.80[0.22; 2.94]1322 -NAHuisjes - Clonidine, 1986 1 Tags Adjustment   - No  - No 0.80[0.22; 2.94]1322 -NAHuisjes - Clonidine, 1986 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 0.80[0.22; 2.94]1322 -NAHuisjes - Clonidine, 1986 1 MatchedMatched 0.80[0.22; 2.94]1322 -NAHuisjes - Clonidine, 1986 1 All studiesAll studies 0.80[0.22; 2.94]1322 -NAHuisjes - Clonidine, 1986 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.80[0.22; 2.94]1322 -NAHuisjes - Clonidine, 1986 10.510.01.0