Centrally acting antiadrenergic (versus unexposed) updated on 03-11-2025

Cognitive developmental disorders/delay (3-6 years old)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13814
R54148		 Chan - Methyldopa, 2010 Full-Scale Intellectual Quotient (IQ) - Wechsler Preschool and Primary Scale of Intelligence (WPPSI-III) - Age 3 to 7 years during pregnancy (anytime or not specified) prospective cohort unexposed, disease free Adjustment: No extrapolated (cont. endpoint) Indications Antihypertensive: All hypertensions, any indications or not specified Matched 2.75 [1.10;6.87] -/25   -/42 - 25
ref
Total 1 studies 2.75 [1.10;6.87] 0 25
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Chan - Methyldopa, 2010Chan - Methyldopa, 2010 2.75[1.10; 6.87]-250%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: lowROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.75[1.10; 6.87]-25 -NAChan - Methyldopa, 2010 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.75[1.10; 6.87]-25 -NAChan - Methyldopa, 2010 1 Tags Adjustment   - No  - No 2.75[1.10; 6.87]-25 -NAChan - Methyldopa, 2010 1 extrapolated (cont. endpoint)extrapolated (cont. endpoint) 2.75[1.10; 6.87]-25 -NAChan - Methyldopa, 2010 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 2.75[1.10; 6.87]-25 -NAChan - Methyldopa, 2010 1 MatchedMatched 2.75[1.10; 6.87]-25 -NAChan - Methyldopa, 2010 1 All studiesAll studies 2.75[1.10; 6.87]-25 -NAChan - Methyldopa, 2010 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.75[1.10; 6.87]-25 -NAChan - Methyldopa, 2010 10.510.01.0