Centrally acting antiadrenergic (versus unexposed) - Medication and Pregnancy KB

Centrally acting antiadrenergic (versus unexposed) updated on 03-11-2025

Very low Apgar score (< 5) (at 1 min)

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S13954 R54645	Sibai - Methyldopa (Controls unexposed, sick), 1990	Apgar score<5 at 1minute	2nd and/or 3rd trimester	randomized controlled trial	unexposed, sick	Adjustment: Randomisation Indications Antihypertensive: Only chronic hypertension indication	0.62 [0.19;1.97] ^C	5/88 8/90	13	88		ref
					Total	1 studies	0.62 [0.19;1.97]		13	88
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed, sick;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Umbrella review (other published meta-analyses)