Centrally acting antiadrenergic (versus unexposed) updated on 03-11-2025

Perinatal death

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13479
R51992		 Orbach - Methyldopa, 2013 Perinatal death (NOS) 3rd trimester retrospective cohort (claims database) unexposed, disease free Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified 2.05 [1.05;4.02] 9/340   1,379/97,820 1,388 340
ref
S13538
R52305		 Weitz - Methyldopa, 1987 Perinatal deaths during pregnancy (anytime or not specified) randomized controlled trial unexposed, sick Adjustment: Randomisation Indications Antihypertensive: Only chronic hypertension indication 0.92 [0.02;50.28] C 0/13   0/12 0 13
ref
S13386
R52202		 Mabie - Methyldopa, 1986 Perinatal death (stillbirth and neonatal deaths) during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No Indications Antihypertensive: Only chronic hypertension indication 1.53 [0.09;24.97] C 1/54   1/82 2 54
ref
S14258
R56061		 Leather - Methyldopa, 1968 Perinatal death during pregnancy (anytime or not specified) randomized controlled trial unexposed, sick Adjustment: Randomisation Co-administration Indications Antihypertensive: Only chronic hypertension indication 0.19 [0.01;4.21] C 0/23   2/24 2 23
ref
Total 4 studies 1.79 [0.95;3.37] 1,392 430
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Orbach - Methyldopa, 2013Orbach - Methyldopa, 2013 2.05[1.05; 4.02]1,38834088%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Weitz - Methyldopa, 1987Weitz - Methyldopa, 1987 0.92[0.02; 50.28]0132%ROB confusion: lowROB selection: unclearROB classification: lowROB missing: lowROB mesure: lowROB reporting: moderate Mabie - Methyldopa, 1986Mabie - Methyldopa, 1986 1.53[0.09; 24.97]2545%ROB confusion: criticalROB selection: moderateROB classification: unclearROB missing: unclearROB mesure: moderateROB reporting: moderate Leather - Methyldopa, 1968Leather - Methyldopa, 1968 0.19[0.01; 4.21]2234%ROB confusion: lowROB selection: unclearROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (4 studies) I2 = 0% 1.79[0.95; 3.37]1,3924300.05.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.02[1.05; 3.87]1,3903940%NAOrbach - Methyldopa, 2013 Mabie - Methyldopa, 1986 2 case control studiescase control studies 0 RCTRCT 0.34[0.03; 3.98]2360%NAWeitz - Methyldopa, 1987 Leather - Methyldopa, 1968 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.05[1.05; 4.01]1,388340 -NAOrbach - Methyldopa, 2013 1 unexposed, sickunexposed, sick 0.66[0.10; 4.14]4900%NAWeitz - Methyldopa, 1987 Mabie - Methyldopa, 1986 Leather - Methyldopa, 1968 3 Tags Adjustment   - No  - No 1.53[0.09; 24.97]254 -NAMabie - Methyldopa, 1986 1   - Randomisation  - Randomisation 0.34[0.03; 3.98]2360%NAWeitz - Methyldopa, 1987 Leather - Methyldopa, 1968 2   - Yes  - Yes 2.05[1.05; 4.01]1,388340 -NAOrbach - Methyldopa, 2013 1 Co-administrationCo-administration 0.19[0.01; 4.21]223 -NALeather - Methyldopa, 1968 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 2.05[1.05; 4.01]1,388340 -NAOrbach - Methyldopa, 2013 1   - Only chronic hypertension indication  - Only chronic hypertension indication 0.66[0.10; 4.14]4900%NAWeitz - Methyldopa, 1987 Mabie - Methyldopa, 1986 Leather - Methyldopa, 1968 3 All studiesAll studies 1.79[0.95; 3.37]1,3924300%NAOrbach - Methyldopa, 2013 Weitz - Methyldopa, 1987 Mabie - Methyldopa, 1986 Leather - Methyldopa, 1968 40.05.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-4.85.42.4500.000Orbach - Methyldopa, 2013Weitz - Methyldopa, 1987Mabie - Methyldopa, 1986Leather - Methyldopa, 1968

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.05[1.05; 4.01]1,388340 -NAOrbach - Methyldopa, 2013 1 unexposed, sick controlsunexposed, sick controls 0.66[0.10; 4.14]4900%NAWeitz - Methyldopa, 1987 Mabie - Methyldopa, 1986 Leather - Methyldopa, 1968 30.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Bone - Methyldopa - GESTATIONAL HYPERTENSION ...Bone - Methyldopa - GESTATIONAL HYPERTENSION (Perinatal death) Out of scale0.44[0.18; 1.15]27%-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT-9 Bellos - Methyldopa (Perinatal death (Randomi ...Bellos - Methyldopa (Perinatal death (Randomized controlled trial and Cohort studies)) 0.88[0.46; 1.70]NA-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT-9 Bellos - Methyldopa (Perinatal death (Randomi ...Bellos - Methyldopa (Perinatal death (Randomized controlled trial only)) 0.61[0.29; 1.28]NA-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT-9 Bone - Methyldopa - GESTATIONAL HYPERTENSION ...Bone - Methyldopa - GESTATIONAL HYPERTENSION (Perinatal death (versus beta-blockers)) 1.14[0.47; 2.70]27%-Eexposed to other treatment, sickAnyduring pregnancy (anytime or not specified)studies TTT-9 Webster (Stillbirth and neonatal death)Webster (Stillbirth and neonatal death) 2.24[0.35; 14.28]0%-Eexposed to other treatment, sickAnyduring pregnancy (anytime or not specified)studies TTT2 metaPregmetaPreg 1.79[0.95; 3.37]0%430----Orbach - Methyldopa, 2013 Weitz - Methyldopa, 1987 Mabie - Methyldopa, 1986 Leather - Methyldopa, 1968 40.510.01.0