Centrally acting antiadrenergic (versus unexposed) - Medication and Pregnancy KB

Centrally acting antiadrenergic (versus unexposed) updated on 03-11-2025

Low Apgar score (< 7) (at 5 min)

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S13479 R51994	Orbach - Methyldopa, 2013	Apgar score <=7 at 5 min	3rd trimester	retrospective cohort (claims database)	unexposed, disease free	Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified	2.84 [1.50;5.38]	10/340 1,026/97,820	1,036	340		ref
S13954 R54646	Sibai - Methyldopa (Controls unexposed, sick), 1990	Apgar score <7 at 5 minutes	2nd and/or 3rd trimester	randomized controlled trial	unexposed, sick	Adjustment: Randomisation Indications Antihypertensive: Only chronic hypertension indication	0.50 [0.09;2.80] ^C	2/88 4/90	6	88		ref
S13946 R54581	Fidler - Methyldopa, 1983	Apgar score < 7 (at 5 min)	during pregnancy (anytime or not specified)	prospective cohort	unexposed, disease free	Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified Matched	0.63 [0.06;6.24] ^C	1/49 3/94	4	49		ref
					Total	3 studies	1.27 [0.35;4.60]		1,046	477
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed, sick;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded