Centrally acting antiadrenergic (versus unexposed) updated on 03-11-2025

Neural Tube Defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13410
R51613		 Medveczky - Methyldopa, 2004 Neural-tube defects 1st trimester case control unexposed (general population or NOS) Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified Matched 0.50 [0.03;8.23] C 0/31   1,202/39,322 1,202 31
ref
Total 1 studies 0.50 [0.03;8.23] 1,202 31
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Medveczky - Methyldopa, 2004Medveczky - Methyldopa, 2004 0.50[0.03; 8.23]1,202310%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: moderateROB mesure: criticalROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0.50[0.03; 8.23]1,20231 -NAMedveczky - Methyldopa, 2004 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.50[0.03; 8.23]1,20231 -NAMedveczky - Methyldopa, 2004 1 Tags Adjustment   - No  - No 0.50[0.03; 8.23]1,20231 -NAMedveczky - Methyldopa, 2004 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 0.50[0.03; 8.23]1,20231 -NAMedveczky - Methyldopa, 2004 1 MatchedMatched 0.50[0.03; 8.23]1,20231 -NAMedveczky - Methyldopa, 2004 1 All studiesAll studies 0.50[0.03; 8.23]1,20231 -NAMedveczky - Methyldopa, 2004 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.50[0.03; 8.23]1,20231 -NAMedveczky - Methyldopa, 2004 10.510.01.0