Centrally acting antiadrenergic (versus unexposed) - Medication and Pregnancy KB

Centrally acting antiadrenergic (versus unexposed) updated on 03-11-2025

Ventricular septal defect

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S14245 R55975	Fisher - Centrally acting antiadrenergics (Controls unexposed, disease free), 2017	Perimembranous Ventricular septal defect (VSD)	early pregnancy	case control	unexposed, disease free excluded	Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified	1.10 [0.44;2.73] excluded (control group)	6/- -/-	-	-		ref
S14247 R55992	Fisher - Centrally acting antiadrenergics (Controls unexposed, sick), 2017	Perimembranous Ventricular septal defect (VSD)	early pregnancy	case control	unexposed, sick	Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified	1.21 [0.46;3.23]	6/- -/-	-	-		ref
					Total	1 studies	1.21 [0.46;3.21]		0	0
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed, sick;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 14245