Ondansetron

Preterm (< 37 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2778
R3780		 Fejzo (Mainly exposed to other treatements, sick), 2016 Preterm birth (21–36 weeks) 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 2.03 [1.36;3.11]
excluded (control group) 		97/1,070   36/771 133 1,070
ref
S2776
R3742		 Fejzo (Unexposed control, disease free), 2016 Preterm birth (21–36 weeks) 1st trimester retrospective cohort unexposed, disease free Adjustment: No 2.11 [1.52;2.95] 97/1,070   70/1,555 167 1,070
ref
S3184
R5100		 Ozdemirci, 2014 Preterm delivery (NOS) 1st trimester retrospective cohort exposed to other treatment, sick Adjustment: No 0.84 [0.32;2.21] C 9/100   9/85 18 100
ref
S2775
R3725		 Colvin, 2013 Preterm birth, <37 wks during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 1.40 [0.70;2.50] 34/251   7,872/96,447 7,906 251
ref
S2746
R3639		 Pasternak, 2013 Preterm delivery (before 37 completed gestational weeks) during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 0.90 [0.66;1.25] 111/1,792   374/7,168 485 1,792
ref
Total 4 studies 1.28 [0.76;2.15] 8,576 3,213
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Fejzo (Unexposed control, disease free), 2016Fejzo, 2016 1 2.11[1.52; 2.95]1671,07031%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Ozdemirci, 2014Ozdemirci, 2014 0.84[0.32; 2.21]1810016%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Colvin, 2013Colvin, 2013 1.40[0.70; 2.50]7,90625123%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Pasternak, 2013Pasternak, 2013 0.90[0.66; 1.25]4851,79231%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (4 studies) I2 = 79% 1.28[0.76; 2.15]8,5763,2130.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Unexposed control, disease free;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.28[0.76; 2.15]8,5763,21379%NAFejzo (Unexposed control, disease free), 2016 Ozdemirci, 2014 Colvin, 2013 Pasternak, 2013 4 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.38[0.76; 2.51]8,5583,11385%NAFejzo (Unexposed control, disease free), 2016 Colvin, 2013 Pasternak, 2013 3 exposed to other treatment, sickexposed to other treatment, sick 0.84[0.32; 2.21]18100 -NAOzdemirci, 2014 1 Tags Adjustment   - No  - No 1.49[0.62; 3.59]1851,17068%NAFejzo (Unexposed control, disease free), 2016 Ozdemirci, 2014 2   - Yes  - Yes 1.03[0.69; 1.53]8,3912,04332%NAColvin, 2013 Pasternak, 2013 2 All studiesAll studies 1.28[0.76; 2.15]8,5763,21379%NAFejzo (Unexposed control, disease free), 2016 Ozdemirci, 2014 Colvin, 2013 Pasternak, 2013 40.25.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-1.21.40.5960.000Fejzo (Unexposed control, disease free), 2016Ozdemirci, 2014Colvin, 2013Pasternak, 2013

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded 2778

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.38[0.76; 2.51]8,5583,11385%NAFejzo (Unexposed control, disease free), 2016 Colvin, 2013 Pasternak, 2013 3 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.46[0.63; 3.38]1511,17063%NAFejzo (Mainly exposed to other treatements, sick), 2016 Ozdemirci, 2014 20.510.01.0