Ondansetron

Elective/induced termination of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2778
R4603		 Fejzo (Mainly exposed to other treatements, sick), 2016 Terminations of pregnancy (1-12 and 13-20 weeks) 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.23 [0.16;0.34] C
excluded (control group) 		37/1,070   104/771 141 1,070
ref
S2776
R4602		 Fejzo (Unexposed control, disease free), 2016 Terminations of pregnancy (1-12 and 13-20 weeks) 1st trimester retrospective cohort unexposed, disease free Adjustment: No 1.10 [0.71;1.70] C 37/1,070   49/1,555 86 1,070
ref
Total 1 studies 1.10 [0.71;1.70] 86 1,070
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Fejzo (Unexposed control, disease free), 2016Fejzo, 2016 1 1.10[0.71; 1.70]861,0700%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Unexposed control, disease free;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.10[0.71; 1.70]861,070 -NAFejzo (Unexposed control, disease free), 2016 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.10[0.71; 1.70]861,070 -NAFejzo (Unexposed control, disease free), 2016 1 Tags Adjustment   - No  - No 1.10[0.71; 1.70]861,070 -NAFejzo (Unexposed control, disease free), 2016 1 All studiesAll studies 1.10[0.71; 1.70]861,070 -NAFejzo (Unexposed control, disease free), 2016 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 2778

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.10[0.71; 1.70]861,070 -NAFejzo (Unexposed control, disease free), 2016 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.23[0.16; 0.34]1411,070 -NAFejzo (Mainly exposed to other treatements, sick), 2016 10.510.01.0