Ondansetron

Low Apgar score (< 7) (at 5 min)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2861
R3999		 Marciniak, 2015 Apgar score et 5 min (< 8) late pregnancy randomized controlled trial unexposed, sick Adjustment: Randomisation Intravenous 0.97 [0.02;50.37] C 0/35   0/34 0 35
ref
S2775
R3716		 Colvin, 2013 APGAR 5 mins < 6 during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 2.00 [0.60;6.10] -/-   576/97,427 567 -
ref
Total 2 studies 1.89 [0.62;5.75] 567 35
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Marciniak, 2015Marciniak, 2015 0.97[0.02; 50.37]0358%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Colvin, 2013Colvin, 2013 2.00[0.60; 6.10]567-92%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 1.89[0.62; 5.75]567350.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.00[0.63; 6.38]567- -NAColvin, 2013 1 case control studiescase control studies 0 RCTRCT 0.97[0.02; 50.37]-35 -NAMarciniak, 2015 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.00[0.63; 6.38]567- -NAColvin, 2013 1 unexposed, sickunexposed, sick 0.97[0.02; 50.37]-35 -NAMarciniak, 2015 1 Tags Adjustment   - No  - No 2.00[0.63; 6.38]567- -NAColvin, 2013 1   - Randomisation  - Randomisation 0.97[0.02; 50.37]-35 -NAMarciniak, 2015 1 IntravenousIntravenous 0.97[0.02; 50.37]-35 -NAMarciniak, 2015 1 All studiesAll studies 1.89[0.62; 5.75]567350%NAMarciniak, 2015 Colvin, 2013 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.00[0.63; 6.38]567- -NAColvin, 2013 1 unexposed, sick controlsunexposed, sick controls 0.97[0.02; 50.37]-35 -NAMarciniak, 2015 10.510.01.0