Ondansetron

Spina bifida

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2853
R3962		 Parker, BDS study, 2018 Spina bifida 1st trimester case control unexposed, sick Adjustment: Yes 1.40 [0.80;2.50] 15/390   135/5,633 150 390
ref
S2756
R3677		 Parker, NBDPS study, 2018 Spina bifida 1st trimester case control unexposed, sick Adjustment: Yes 1.10 [0.60;1.80] 18/230   293/3,348 311 230
ref
Total 2 studies 1.24 [0.83;1.83] 461 620
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Parker, BDS study, 2018Parker, BDS study, 2018 1.40[0.80; 2.50]15039048%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Parker, NBDPS study, 2018Parker, NBDPS study, 2018 1.10[0.60; 1.80]31123052%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 1.24[0.83; 1.83]4616200.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.24[0.83; 1.83]4616200%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 2 Type of controls unexposed, sickunexposed, sick 1.24[0.83; 1.83]4616200%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 2 Tags Adjustment   - Yes  - Yes 1.24[0.83; 1.83]4616200%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 2 All studiesAll studies 1.24[0.83; 1.83]4616200%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.24[0.83; 1.83]4616200%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 20.510.01.0