Ondansetron

Transposition of the great vessels

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2853
R3985		 Parker, BDS study, 2018 Transposition of the great arteries 1st trimester case control unexposed, sick Adjustment: Yes 0.80 [0.40;1.60] 8/383   128/5,628 136 383
ref
S2756
R3702		 Parker, NBDPS study, 2018 Transposition of the great arteries 1st trimester case control unexposed, sick Adjustment: Yes 0.80 [0.50;1.50] 13/266   435/6,933 448 266
ref
Total 2 studies 0.80 [0.52;1.23] 584 649
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Parker, BDS study, 2018Parker, BDS study, 2018 0.80[0.40; 1.60]13638339%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Parker, NBDPS study, 2018Parker, NBDPS study, 2018 0.80[0.50; 1.50]44826661%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 0.80[0.52; 1.23]5846490.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0.80[0.52; 1.23]5846490%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 2 Type of controls unexposed, sickunexposed, sick 0.80[0.52; 1.23]5846490%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 2 Tags Adjustment   - Yes  - Yes 0.80[0.52; 1.23]5846490%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 2 All studiesAll studies 0.80[0.52; 1.23]5846490%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.80[0.52; 1.23]5846490%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 20.510.01.0