Ondansetron

Craniosynostosis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2757
R3954		 Zambelli-Weiner (Unexposed control, NOS), 2019 Craniosynostosis 1st trimester nested case control unexposed (general population or NOS) Adjustment: Yes 1.11 [0.90;1.36] 94/972   11,759/124,865 11,853 972
ref
S2756
R3694		 Parker, NBDPS study, 2018 Craniosynostosis 1st trimester case control unexposed, sick Adjustment: Yes 1.20 [0.80;1.60] 54/307   854/7,352 908 307
ref
S2746
R3934		 Pasternak, 2013 Craniosynostosis 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: No 1.33 [0.14;12.83] C 1/1,233   3/4,932 4 1,233
ref
Total 3 studies 1.13 [0.95;1.35] 12,765 2,512
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Zambelli-Weiner (Unexposed control, NOS), 2019Zambelli-Weiner, 2019 1 1.11[0.90; 1.36]11,85397273%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Parker, NBDPS study, 2018Parker, NBDPS study, 2018 1.20[0.80; 1.60]90830726%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Pasternak, 2013Pasternak, 2013 1.33[0.14; 12.83]41,2331%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (3 studies) I2 = 0% 1.13[0.95; 1.35]12,7652,5120.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Unexposed control, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.33[0.14; 12.83]41,233 -NAPasternak, 2013 1 case control studiescase control studies 1.13[0.95; 1.35]12,7611,2790%NAZambelli-Weiner (Unexposed control, NOS), 2019 Parker, NBDPS study, 2018 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.11[0.91; 1.37]11,8572,2050%NAZambelli-Weiner (Unexposed control, NOS), 2019 Pasternak, 2013 2 unexposed, sickunexposed, sick 1.20[0.85; 1.70]908307 -NAParker, NBDPS study, 2018 1 Tags Adjustment   - No  - No 1.33[0.14; 12.83]41,233 -NAPasternak, 2013 1   - Yes  - Yes 1.13[0.95; 1.35]12,7611,2790%NAZambelli-Weiner (Unexposed control, NOS), 2019 Parker, NBDPS study, 2018 2 All studiesAll studies 1.13[0.95; 1.35]12,7652,5120%NAZambelli-Weiner (Unexposed control, NOS), 2019 Parker, NBDPS study, 2018 Pasternak, 2013 30.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.11[0.91; 1.37]11,8572,2050%NAZambelli-Weiner (Unexposed control, NOS), 2019 Pasternak, 2013 2 unexposed, sick controlsunexposed, sick controls 1.20[0.85; 1.70]908307 -NAParker, NBDPS study, 2018 10.510.01.0