Ondansetron

Limb reduction defects (LRD)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2757
R3957		 Zambelli-Weiner (Unexposed control, NOS), 2019 Limb reduction defects 1st trimester nested case control unexposed (general population or NOS) Adjustment: Yes 1.03 [0.38;2.75] 4/882   557/113,663 561 882
ref
S2746
R3932		 Pasternak, 2013 Reduction defect of upper limb 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: No 0.80 [0.04;16.67] C 0/1,233   2/4,932 2 1,233
ref
Total 2 studies 1.01 [0.39;2.58] 563 2,115
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Zambelli-Weiner (Unexposed control, NOS), 2019Zambelli-Weiner, 2019 1 1.03[0.38; 2.75]56188290%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Pasternak, 2013Pasternak, 2013 0.80[0.04; 16.67]21,23310%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 1.01[0.39; 2.58]5632,1150.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Unexposed control, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.80[0.04; 16.67]21,233 -NAPasternak, 2013 1 case control studiescase control studies 1.03[0.38; 2.77]561882 -NAZambelli-Weiner (Unexposed control, NOS), 2019 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.01[0.39; 2.58]5632,1150%NAZambelli-Weiner (Unexposed control, NOS), 2019 Pasternak, 2013 2 Tags Adjustment   - No  - No 0.80[0.04; 16.67]21,233 -NAPasternak, 2013 1   - Yes  - Yes 1.03[0.38; 2.77]561882 -NAZambelli-Weiner (Unexposed control, NOS), 2019 1 All studiesAll studies 1.01[0.39; 2.58]5632,1150%NAZambelli-Weiner (Unexposed control, NOS), 2019 Pasternak, 2013 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.01[0.39; 2.58]5632,1150%NAZambelli-Weiner (Unexposed control, NOS), 2019 Pasternak, 2013 20.510.01.0