Ondansetron

Hypospadias

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2853
R3965		 Parker, BDS study, 2018 Hypospadias 1st-, 2nd-, or 3rd-degree 1st trimester case control unexposed, sick Adjustment: Yes 1.00 [0.60;1.50] 30/405   372/5,870 402 405
ref
S2756
R3681		 Parker, NBDPS study, 2018 Hypospadias 2nd- or 3rd-degree 1st trimester case control unexposed, sick Adjustment: Yes 0.80 [0.50;1.10] 45/145   668/2,027 713 145
ref
S4901
R12950		 Lind, 2013 Isolated Second- or Third-Degree Hypospadias 1st trimester case control unexposed (general population or NOS) Adjustment: Yes 1.00 [0.60;1.70] 23/68   1,514/5,783 1,537 68
ref
S2746
R3905		 Pasternak, 2013 Hypospadias 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: No 1.33 [0.43;4.14] C 4/1,233   12/4,932 16 1,233
ref
S2747
R3647		 Anderka, 2012 Hypospadias 1st trimester case control unexposed, sick Adjustment: Yes 0.57 [0.20;1.60] 5/23   650/2,588 655 23
ref
Total 5 studies 0.90 [0.70;1.15] 3,323 1,874
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Parker, BDS study, 2018Parker, BDS study, 2018 1.00[0.60; 1.50]40240529%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Parker, NBDPS study, 2018Parker, NBDPS study, 2018 0.80[0.50; 1.10]71314539%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Lind, 2013Lind, 2013 1.00[0.60; 1.70]1,5376822%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Pasternak, 2013Pasternak, 2013 1.33[0.43; 4.14]161,2335%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Anderka, 2012Anderka, 2012 0.57[0.20; 1.60]655236%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (5 studies) I2 = 0% 0.90[0.70; 1.15]3,3231,8740.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.33[0.43; 4.14]161,233 -NAPasternak, 2013 1 case control studiescase control studies 0.88[0.69; 1.14]3,3076410%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 Lind, 2013 Anderka, 2012 4 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.05[0.66; 1.69]1,5531,3010%NALind, 2013 Pasternak, 2013 2 unexposed, sickunexposed, sick 0.85[0.64; 1.13]1,7705730%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 Anderka, 2012 3 Tags Adjustment   - No  - No 1.33[0.43; 4.14]161,233 -NAPasternak, 2013 1   - Yes  - Yes 0.88[0.69; 1.14]3,3076410%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 Lind, 2013 Anderka, 2012 4 All studiesAll studies 0.90[0.70; 1.15]3,3231,8740%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 Lind, 2013 Pasternak, 2013 Anderka, 2012 50.25.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-1.41.30.6940.000Parker, BDS study, 2018Parker, NBDPS study, 2018Lind, 2013Pasternak, 2013Anderka, 2012

Asymetry test p-value = 0.9264 (by Egger's regression)

slope=-0.1300 (0.2742); intercept=0.0983 (0.9790); t=0.1004; p=0.9264

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.05[0.66; 1.69]1,5531,3010%NALind, 2013 Pasternak, 2013 2 unexposed, sick controlsunexposed, sick controls 0.85[0.64; 1.13]1,7705730%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 Anderka, 2012 30.510.01.0