Ondansetron

Preeclampsia

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3184
R5101		 Ozdemirci, 2014 Pregnancy induced hypertension 1st trimester retrospective cohort exposed to other treatment, sick Adjustment: No 4.33 [0.21;91.53] C 2/100   0/85 2 100
ref
S2775
R3731		 Colvin, 2013 Preeclampsia during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 1.50 [0.90;2.50] 17/251   4,343/96,447 4,360 251
ref
Total 2 studies 1.54 [0.93;2.56] 4,362 351
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ozdemirci, 2014Ozdemirci, 2014 4.33[0.21; 91.53]21003%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Colvin, 2013Colvin, 2013 1.50[0.90; 2.50]4,36025197%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 1.54[0.93; 2.56]4,3623510.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.54[0.93; 2.56]4,3623510%NAOzdemirci, 2014 Colvin, 2013 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.50[0.90; 2.50]4,360251 -NAColvin, 2013 1 exposed to other treatment, sickexposed to other treatment, sick 4.33[0.21; 91.53]2100 -NAOzdemirci, 2014 1 Tags Adjustment   - No  - No 1.54[0.93; 2.56]4,3623510%NAOzdemirci, 2014 Colvin, 2013 2 All studiesAll studies 1.54[0.93; 2.56]4,3623510%NAOzdemirci, 2014 Colvin, 2013 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.50[0.90; 2.50]4,360251 -NAColvin, 2013 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 4.33[0.21; 91.53]2100 -NAOzdemirci, 2014 10.510.01.0