Ondansetron

Neonatal medical care

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2856
R4590		 Shahraki, 2016 Intensive care admission during pregnancy (anytime or not specified) randomized controlled trial exposed to other treatment, sick Adjustment: Randomisation 1.45 [0.38;5.56] C 5/88   4/100 9 88
ref
S2775
R3721		 Colvin, 2013 Resuscitated at birth during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 1.20 [0.90;1.50] 125/263   42,376/98,062 42,501 263
ref
Total 2 studies 1.21 [0.94;1.55] 42,510 351
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Shahraki, 2016Shahraki, 2016 1.45[0.38; 5.56]9883%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Colvin, 2013Colvin, 2013 1.20[0.90; 1.50]42,50126397%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 1.21[0.94; 1.55]42,5103510.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.20[0.93; 1.55]42,501263 -NAColvin, 2013 1 case control studiescase control studies 0 RCTRCT 1.45[0.38; 5.56]988 -NAShahraki, 2016 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.20[0.93; 1.55]42,501263 -NAColvin, 2013 1 exposed to other treatment, sickexposed to other treatment, sick 1.45[0.38; 5.56]988 -NAShahraki, 2016 1 Tags Adjustment   - No  - No 1.20[0.93; 1.55]42,501263 -NAColvin, 2013 1   - Randomisation  - Randomisation 1.45[0.38; 5.56]988 -NAShahraki, 2016 1 All studiesAll studies 1.21[0.94; 1.55]42,5103510%NAShahraki, 2016 Colvin, 2013 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.20[0.93; 1.55]42,501263 -NAColvin, 2013 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.45[0.38; 5.56]988 -NAShahraki, 2016 10.510.01.0