Domperidone

Early intrauterine death (< 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2835
R3803		 Cottin (Control exposed to other treatments), 2015 Spontaneous abortions (NOS) 1st trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No 1.36 [0.39;4.79] C
excluded (control group) 		7/119   4/91 11 119
ref
S2825
R3800		 Cottin (Controls unexposed, disease free), 2015 Spontaneous abortions (NOS) 1st trimester prospective cohort unexposed, disease free Adjustment: No 0.77 [0.31;1.89] C 7/119   18/239 25 119
ref
S2740
R3608		 Choi, 2013 Spontaneous abortion (NOS) 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No 1.30 [0.40;4.10] 5/125   7/220 12 125
ref
Total 2 studies 0.94 [0.46;1.91] 37 244
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Cottin (Controls unexposed, disease free), 2015Cottin, 2015 1 0.77[0.31; 1.89]2511962%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Choi, 2013Choi, 2013 1.30[0.40; 4.10]1212538%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 0.94[0.46; 1.91]372440.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, disease free;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.94[0.46; 1.91]372440%NACottin (Controls unexposed, disease free), 2015 Choi, 2013 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.94[0.46; 1.91]372440%NACottin (Controls unexposed, disease free), 2015 Choi, 2013 2 Tags Adjustment   - No  - No 0.94[0.46; 1.91]372440%NACottin (Controls unexposed, disease free), 2015 Choi, 2013 2 All studiesAll studies 0.94[0.46; 1.91]372440%NACottin (Controls unexposed, disease free), 2015 Choi, 2013 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 2835

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.94[0.46; 1.91]372440%NACottin (Controls unexposed, disease free), 2015 Choi, 2013 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.36[0.39; 4.79]11119 -NACottin (Control exposed to other treatments), 2015 10.510.01.0