Metoclopramide

Low birth weight (< 2500g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2404
R3054		 Ashkenazi-Hoffnung, 2013 Low birth weight (< 2500 g) at least 1st trimester prospective cohort exposed to other treatment, sick Adjustment: No 0.13 [0.01;2.59] C 0/28   3/28 3 28
ref
S2397
R3005		 Pasternak, 2013 Low birth weight (< 2,500 g) during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 0.98 [0.92;1.05] 1,270/36,864   4,985/147,016 6,255 36,864
ref
S2395
R2977		 Matok, 2009 Low birth weight (< 2,500 g) 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 1.01 [0.89;1.14] 295/3,458   6,497/78,245 6,792 3,458
ref
S2751
R3656		 Asker, 2005 Low birth weight during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 0.86 [0.79;0.90] 28/1,166   21,086/665,572 21,114 1,166
ref
S2407
R3064		 Sorensen, 2000 Low birth weight (< 2,500 g) 2nd and/or 3rd trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 1.79 [0.83;3.86] 18/295   657/13,327 675 295
ref
Total 5 studies 0.95 [0.85;1.07] 34,839 41,811
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ashkenazi-Hoffnung, 2013Ashkenazi-Hoffnung, 2013 0.13[0.01; 2.59]3280%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Pasternak, 2013Pasternak, 2013 0.98[0.92; 1.05]6,25536,86435%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Matok, 2009Matok, 2009 1.01[0.89; 1.14]6,7923,45827%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Asker, 2005Asker, 2005 0.86[0.79; 0.90]21,1141,16635%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Sorensen, 2000Sorensen, 2000 1.79[0.83; 3.86]6752952%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (5 studies) I2 = 72% 0.95[0.85; 1.07]34,83941,8110.05.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.95[0.85; 1.07]34,83941,81172%NAAshkenazi-Hoffnung, 2013 Pasternak, 2013 Matok, 2009 Asker, 2005 Sorensen, 2000 5 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.95[0.85; 1.06]34,83641,78376%NAPasternak, 2013 Matok, 2009 Asker, 2005 Sorensen, 2000 4 exposed to other treatment, sickexposed to other treatment, sick 0.13[0.01; 2.59]328 -NAAshkenazi-Hoffnung, 2013 1 Tags Adjustment   - No  - No 0.13[0.01; 2.59]328 -NAAshkenazi-Hoffnung, 2013 1   - Yes  - Yes 0.95[0.85; 1.06]34,83641,78376%NAPasternak, 2013 Matok, 2009 Asker, 2005 Sorensen, 2000 4 All studiesAll studies 0.95[0.85; 1.07]34,83941,81172%NAAshkenazi-Hoffnung, 2013 Pasternak, 2013 Matok, 2009 Asker, 2005 Sorensen, 2000 50.05.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-3.63.61.8450.000Ashkenazi-Hoffnung, 2013Pasternak, 2013Matok, 2009Asker, 2005Sorensen, 2000

Asymetry test p-value = 0.7820 (by Egger's regression)

slope=-0.0907 (0.0755); intercept=0.4617 (1.5260); t=0.3026; p=0.7820

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.95[0.85; 1.06]34,83641,78376%NAPasternak, 2013 Matok, 2009 Asker, 2005 Sorensen, 2000 4 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.13[0.01; 2.59]328 -NAAshkenazi-Hoffnung, 2013 10.510.01.0