Metoclopramide

Late intrauterine deaths (> 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2397
R3003		 Pasternak, 2013 Stillbirth (> 22 weeks) throughout pregnancy population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 0.90 [0.74;1.08] 142/40,306   634/161,098 776 40,306
ref
S2395
R2976		 Matok, 2009 Perinatal death 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 0.87 [0.55;1.38] 53/3,458   1,708/78,245 1,761 3,458
ref
S2407
R13251		 Sorensen, 2000 Stillborn (before birth) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 2.88 [0.38;21.88] C 1/309   15/13,327 16 309
ref
Total 3 studies 0.90 [0.76;1.08] 2,553 44,073
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Pasternak, 2013Pasternak, 2013 0.90[0.74; 1.08]77640,30685%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Matok, 2009Matok, 2009 0.87[0.55; 1.38]1,7613,45814%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Sorensen, 2000Sorensen, 2000 2.88[0.38; 21.88]163091%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (3 studies) I2 = 0% 0.90[0.76; 1.08]2,55344,0730.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.90[0.76; 1.08]2,55344,0730%NAPasternak, 2013 Matok, 2009 Sorensen, 2000 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.90[0.76; 1.08]2,55344,0730%NAPasternak, 2013 Matok, 2009 Sorensen, 2000 3 Tags Adjustment   - No  - No 2.88[0.38; 21.88]16309 -NASorensen, 2000 1   - Yes  - Yes 0.90[0.75; 1.07]2,53743,7640%NAPasternak, 2013 Matok, 2009 2 All studiesAll studies 0.90[0.76; 1.08]2,55344,0730%NAPasternak, 2013 Matok, 2009 Sorensen, 2000 30.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.90[0.76; 1.08]2,55344,0730%NAPasternak, 2013 Matok, 2009 Sorensen, 2000 30.510.01.0