Metoclopramide

Low Apgar score (< 7) (at 5 min)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2395
R2980		 Matok, 2009 Apgar score ≤ 7 (at 5 min) 1st trimester excluded retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 0.84 [0.57;1.22]
excluded (exposition period) 		28/3,458   708/78,245 736 3,458
ref
S2723
R3598		 Shahriari, 2009 Apgar score at 5 min (< 8) late pregnancy randomized controlled trial exposed to other treatment, sick Adjustment: Randomisation Intravenous 1.00 [0.02;51.66] C 0/40   0/40 0 40
ref
S2733
R3605		 Kafle, 1993 Apgar score at 5 min (< 7) late pregnancy randomized controlled trial exposed to other treatment, sick Adjustment: Randomisation Intrathecal 1.00 [0.02;52.45] C 0/25   0/25 0 25
ref
S2401
R3045		 Bylsma-Howell, 1983 Apgar score <= 7 (5 min) late pregnancy randomized controlled trial unexposed, sick Adjustment: Randomisation Intravenous 1.53 [0.03;85.96] C 0/8   0/12 0 8
ref
S2727
R3601		 Howard, 1973 Apgar score at 5 min (< 7) late pregnancy randomized controlled trial unexposed, sick Adjustment: Randomisation Intramuscular 0.92 [0.02;50.28] C 0/13   0/12 0 13
ref
Total 4 studies 1.09 [0.15;7.97] 0 86
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Shahriari, 2009Shahriari, 2009 1.00[0.02; 51.66]04025%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Kafle, 1993Kafle, 1993 1.00[0.02; 52.45]02525%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Bylsma-Howell, 1983Bylsma-Howell, 1983 1.53[0.03; 85.96]0824%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Howard, 1973Howard, 1973 0.92[0.02; 50.28]01325%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (4 studies) I2 = 0% 1.09[0.15; 7.97]-860.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0 RCTRCT 1.09[0.15; 7.97]-860%NAShahriari, 2009 Kafle, 1993 Bylsma-Howell, 1983 Howard, 1973 4 Type of controls unexposed, sickunexposed, sick 1.19[0.07; 20.26]-210%NABylsma-Howell, 1983 Howard, 1973 2 exposed to other treatment, sickexposed to other treatment, sick 1.00[0.06; 16.36]-650%NAShahriari, 2009 Kafle, 1993 2 Tags Adjustment   - Randomisation  - Randomisation 1.09[0.15; 7.97]-860%NAShahriari, 2009 Kafle, 1993 Bylsma-Howell, 1983 Howard, 1973 4 IntramuscularIntramuscular 0.92[0.02; 50.28]-13 -NAHoward, 1973 1 IntrathecalIntrathecal 1.00[0.02; 52.45]-25 -NAKafle, 1993 1 IntravenousIntravenous 1.23[0.07; 20.64]-480%NAShahriari, 2009 Bylsma-Howell, 1983 2 All studiesAll studies 1.09[0.15; 7.97]-860%NAShahriari, 2009 Kafle, 1993 Bylsma-Howell, 1983 Howard, 1973 40.25.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-4.84.92.4650.000Shahriari, 2009Kafle, 1993Bylsma-Howell, 1983Howard, 1973

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.19[0.07; 20.26]-210%NABylsma-Howell, 1983 Howard, 1973 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.00[0.06; 16.36]-650%NAShahriari, 2009 Kafle, 1993 20.510.01.0