Metoclopramide

Low Apgar score (< 7) (at 1 min)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2395
R2979		 Matok, 2009 Apgar score ≤ 7 (at 1 min) 1st trimester excluded retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 0.97 [0.84;1.13]
excluded (exposition period) 		188/3,357   4,149/75,133 4,337 3,357
ref
S2723
R3597		 Shahriari, 2009 Apgar score at 1 min (< 8) late pregnancy randomized controlled trial exposed to other treatment, sick Adjustment: Randomisation Intravenous 1.00 [0.02;51.66] C 0/40   0/40 0 40
ref
S2733
R3604		 Kafle, 1993 Apgar score at 1 min (< 7) late pregnancy randomized controlled trial exposed to other treatment, sick Adjustment: Randomisation Intrathecal 1.00 [0.02;52.45] C 0/25   0/25 0 25
ref
S2401
R3043		 Bylsma-Howell, 1983 Apgar score <= 7 (1 min) late pregnancy randomized controlled trial unexposed, sick Adjustment: Randomisation Intravenous 0.47 [0.02;13.10] C 0/8   1/12 1 8
ref
S2727
R3602		 Howard, 1973 Apgar score at 1 min (< 7) late pregnancy randomized controlled trial unexposed, sick Adjustment: Randomisation Intramuscular 0.92 [0.02;50.28] C 0/13   0/12 0 13
ref
S2734
R3606		 McGarry (Control exposed to perphenazine), 1971 Apgar score at 1 min (< 7) late pregnancy randomized controlled trial exposed to other treatment, sick excluded Adjustment: Randomisation Intramuscular 0.81 [0.43;1.54] C
excluded (control group) 		19/196   23/197 42 196
ref
S2735
R3607		 McGarry (Unexposed control), 1971 Apgar score at 1 min (< 7) late pregnancy randomized controlled trial unexposed, sick Adjustment: Randomisation Intramuscular 1.10 [0.55;2.18] C 19/196   17/191 36 196
ref
Total 5 studies 1.05 [0.55;2.01] 37 282
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Shahriari, 2009Shahriari, 2009 1.00[0.02; 51.66]0403%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Kafle, 1993Kafle, 1993 1.00[0.02; 52.45]0253%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Bylsma-Howell, 1983Bylsma-Howell, 1983 0.47[0.02; 13.10]184%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Howard, 1973Howard, 1973 0.92[0.02; 50.28]0133%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA McGarry (Unexposed control), 1971McGarry, 1971 1 1.10[0.55; 2.18]3619688%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (5 studies) I2 = 0% 1.05[0.55; 2.01]372820.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Unexposed control;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0 RCTRCT 1.05[0.55; 2.01]372820%NAShahriari, 2009 Kafle, 1993 Bylsma-Howell, 1983 Howard, 1973 McGarry (Unexposed control), 1971 5 Type of controls unexposed, sickunexposed, sick 1.06[0.54; 2.05]372170%NABylsma-Howell, 1983 Howard, 1973 McGarry (Unexposed control), 1971 3 exposed to other treatment, sickexposed to other treatment, sick 1.00[0.06; 16.36]-650%NAShahriari, 2009 Kafle, 1993 2 Tags Adjustment   - Randomisation  - Randomisation 1.05[0.55; 2.01]372820%NAShahriari, 2009 Kafle, 1993 Bylsma-Howell, 1983 Howard, 1973 McGarry (Unexposed control), 1971 5 IntramuscularIntramuscular 1.09[0.56; 2.15]362090%NAHoward, 1973 McGarry (Unexposed control), 1971 2 IntrathecalIntrathecal 1.00[0.02; 52.45]-25 -NAKafle, 1993 1 IntravenousIntravenous 0.64[0.05; 8.19]1480%NAShahriari, 2009 Bylsma-Howell, 1983 2 All studiesAll studies 1.05[0.55; 2.01]372820%NAShahriari, 2009 Kafle, 1993 Bylsma-Howell, 1983 Howard, 1973 McGarry (Unexposed control), 1971 50.25.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-4.84.92.4500.000Shahriari, 2009Kafle, 1993Bylsma-Howell, 1983Howard, 1973McGarry (Unexposed control), 1971

Asymetry test p-value = 0.2625 (by Egger's regression)

slope=0.1601 (0.1079); intercept=-0.2016 (0.1465); t=1.3763; p=0.2625

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded 2734

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.06[0.54; 2.05]372170%NABylsma-Howell, 1983 Howard, 1973 McGarry (Unexposed control), 1971 3 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.82[0.44; 1.54]422610%NAShahriari, 2009 Kafle, 1993 McGarry (Control exposed to perphenazine), 1971 30.510.01.0