Metoclopramide

Cleft palate

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3267
R5276		 Huybrechts, 2018 Cleft Palate 1st trimester retrospective cohort (claims database) exposed to other treatment, sick Adjustment: Yes 0.81 [0.53;1.25] 35/52,809   59/77,165 94 52,809
ref
S2397
R2992		 Pasternak, 2013 Cleft palate 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 0.91 [0.51;1.62] 15/28,486   67/113,698 82 28,486
ref
S2749
R3650		 Anderka, 2012 Cleft palate 1st trimester case control unexposed, sick Adjustment: Yes 2.36 [0.85;6.55] 5/23   520/4,511 525 23
ref
Total 3 studies 1.01 [0.63;1.64] 701 81,318
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Huybrechts, 2018Huybrechts, 2018 0.81[0.53; 1.25]9452,80947%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Pasternak, 2013Pasternak, 2013 0.91[0.51; 1.62]8228,48636%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Anderka, 2012Anderka, 2012 2.36[0.85; 6.55]5252317%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (3 studies) I2 = 44% 1.01[0.63; 1.64]70181,3180.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.84[0.60; 1.19]17681,2950%NAHuybrechts, 2018 Pasternak, 2013 2 case control studiescase control studies 2.36[0.85; 6.55]52523 -NAAnderka, 2012 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.91[0.51; 1.62]8228,486 -NAPasternak, 2013 1 unexposed, sickunexposed, sick 2.36[0.85; 6.55]52523 -NAAnderka, 2012 1 exposed to other treatment, sickexposed to other treatment, sick 0.81[0.53; 1.24]9452,809 -NAHuybrechts, 2018 1 Tags Adjustment   - Yes  - Yes 1.01[0.63; 1.64]70181,31844%NAHuybrechts, 2018 Pasternak, 2013 Anderka, 2012 3 All studiesAll studies 1.01[0.63; 1.64]70181,31844%NAHuybrechts, 2018 Pasternak, 2013 Anderka, 2012 30.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.91[0.51; 1.62]8228,486 -NAPasternak, 2013 1 unexposed, sick controlsunexposed, sick controls 2.36[0.85; 6.55]52523 -NAAnderka, 2012 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.81[0.53; 1.24]9452,809 -NAHuybrechts, 2018 10.510.01.0