Valproate (Paternal exposure)

Psychomotor developmental disorders/delay

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18945
R80564		 Meng_Taiwan (Controls exposed to LTG/LEV), 2026 Developmental Coordination Disorder - At least 2 diagnoses on different dates ICD-9 and ICD-10: F82.xx - Follow up: between 6 and 12 years Paternal exposure: genotoxic/epigenetic window (0–xxx months preconception) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: Yes Paternal ASMs: monotherapy 1.65 [0.64;4.26]
excluded (control group) 		47/564   6/96 53 564
ref
S18944
R80556		 Meng_Taiwan (Controls unexposed, sick), 2026 Developmental Coordination Disorder - At least 2 diagnoses on different dates ICD-9 and ICD-10: F82.xx - Follow up: between 6 and 12 years Paternal exposure: genotoxic/epigenetic window (0–xxx months preconception) population based cohort retrospective unexposed, sick Adjustment: Yes Paternal ASMs: monotherapy 1.25 [0.93;1.70] 46/543   27,281/500,498 27,327 543
ref
Total 1 studies 1.25 [0.92;1.69] 27,327 543
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Meng_Taiwan (Controls unexposed, sick), 2026Meng_Taiwan, 2026 1 1.25[0.93; 1.70]27,3275430%ROB confusion: moderateROB selection: lowROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: low0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.25[0.92; 1.69]27,327543 -NAMeng_Taiwan (Controls unexposed, sick), 2026 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.25[0.92; 1.69]27,327543 -NAMeng_Taiwan (Controls unexposed, sick), 2026 1 Tags Adjustment   - Yes  - Yes 1.25[0.92; 1.69]27,327543 -NAMeng_Taiwan (Controls unexposed, sick), 2026 1 Paternal ASMs   - monotherapy  - monotherapy 1.25[0.92; 1.69]27,327543 -NAMeng_Taiwan (Controls unexposed, sick), 2026 1 All studiesAll studies 1.25[0.92; 1.69]27,327543 -NAMeng_Taiwan (Controls unexposed, sick), 2026 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18945

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.25[0.92; 1.69]27,327543 -NAMeng_Taiwan (Controls unexposed, sick), 2026 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.65[0.64; 4.26]53564 -NAMeng_Taiwan (Controls exposed to LTG/LEV), 2026 10.510.01.0