Misoprostol

Preterm (< 37 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2262
R4309		 Vauzelle, 2013 Preterm 1st trimester prospective cohort unexposed, disease free Adjustment: No 3.51 [1.38;8.90] 14/145   6/218 20 145
ref
Total 1 studies 3.51 [1.38;8.91] 20 145
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Vauzelle, 2013Vauzelle, 2013 3.51[1.38; 8.90]201450%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 3.51[1.38; 8.91]20145 -NAVauzelle, 2013 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 3.51[1.38; 8.91]20145 -NAVauzelle, 2013 1 Tags Adjustment   - No  - No 3.51[1.38; 8.91]20145 -NAVauzelle, 2013 1 All studiesAll studies 3.51[1.38; 8.91]20145 -NAVauzelle, 2013 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.51[1.38; 8.91]20145 -NAVauzelle, 2013 10.510.01.0