Misoprostol

All congenital malformations (majors, minors, majors and minors, or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2263
R4348		 Barbero, 2011 Congenital anomalies during pregnancy (anytime or not specified) excluded prospective cohort exposed to other treatment, sick Adjustment: No 3.00 [1.14;7.89] C
excluded (exposition period) 		7/77   12/372 19 77
ref
S2272
R2637		 Dal Pizzol, 2008 Congenital anomalies 1st trimester retrospective cohort unexposed (general population or NOS) Adjustment: Yes 2.64 [1.03;6.75] 5/118   81/4,575 86 118
ref
S2266
R2613		 Brasil, 2000 Congenital anomalies during pregnancy (anytime or not specified) excluded case control Adjustment: Yes Subanalysis hypertensive disorders: SSRI 2.40 [1.00;6.20]
excluded (exposition period) 		6/34   31/390 37 34
ref
Total 1 studies 2.64 [1.03;6.76] 86 118
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Dal Pizzol, 2008Dal Pizzol, 2008 2.64[1.03; 6.75]861180%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.64[1.03; 6.76]86118 -NADal Pizzol, 2008 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.64[1.03; 6.76]86118 -NADal Pizzol, 2008 1 Tags Adjustment   - Yes  - Yes 2.64[1.03; 6.76]86118 -NADal Pizzol, 2008 1 All studiesAll studies 2.64[1.03; 6.76]86118 -NADal Pizzol, 2008 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.64[1.03; 6.76]86118 -NADal Pizzol, 2008 10.510.01.0